Mario Buongiovanni, a university student, tries to make ends meet by doing various jobs: selling encyclopedias, singing in nightclubs, and working as a tour guide. He then became a science teacher at a women's college where he meets Lisa, the daughter of a wealthy industrialist from Lombardy, and falls in love with her. However, Lisa's father is already considering marrying her off to a very rich suitor. Will Mario be able to win Lisa's heart despite the odds? "Lisa with the Blue Eyes" is a heartfelt story of love, ambition, and the challenges of social class, set against the backdrop of 1960s Italy.